Angello's claim to fame came when he released his remix of Eurythmics "Sweet Dreams" in late 2004. Since then, he has established himself in the house music scene with such signature Beatport tracks as "KNAS", "Rave n' Roll" and "Yeah". He also accompanied his size edits for Junior Sanchez and Tim Mason, and made notable remix of the Robin S. track, "Show Me Love". Steve Angello is a prolific producer, with remixes for Pendulum's 'The Island' alongside industry peers Max Vangeli and AN21 and his own cut of Alex Metric's 'Open Your Eyes'. As a producer, his style can mainly be classified as house music with theatrical and epic themes.

Angello has produced under several different aliases. On his own, he has called himself Who's Who and released tracks called "Not So Dirty" and "Sexy Fuck". He often works closely with his childhood friend Sebastian Ingrosso on many projects. Aside from DJing together, they have also produced under the names Buy Now, Fireflies, General Moders, Mode Hookers, Outfunk, and The Sinners.

He has produced with Eric Prydz under the name A&P Project. Also, he has created a track with his friend Axwell under the name Supermongo, later renamed Supermode. They made a cover of an old Bronski Beat track, calling it "Tell Me Why". This was released via Ministry of Sound's Data Records imprint in summer 2006. He is equally famous for the track with Alex Metric "Open Your Eyes", a FIFA 12 track that has been very successful since the release on 13 September of FIFA 12.

Steve Angello was also a member of one of the biggest EDM supergroups in the world, known as Swedish House Mafia, which is composed of him, Sebastian Ingrosso, and Axwell. Under "Swedish House Mafia", they have produced massive hits such as "Save the World", "Antidote", "Greyhound", "One","Miami 2 Ibiza", and "Don't You Worry Child" to name a few.

He also owns his own record label, Size Records, which houses many artists including Tim Mason, Qulinez, Third Party, Junior Sanchez, AN21 & Max Vangeli and supports releases by Tommy Trash, Arno Cost, Marcus Schossow, Moguai, Ivan Gough, Henrix, and Wayne & Woods.

Angello's own live presence has become an increasingly agile display of showmanship and turntable dexterity. Taking the reigns at infamous stages across the globe and boasting annual residencies for the White Isle's most prestigious night spots, not even Madison Square Garden has proven too daunting a task for his uninhibited live persona.

Angello's brother, Antoine Josefsson, is also a DJ and producer who goes by the name of AN21.[3] Together they have released the tracks "Valodja", "Flonko" & "Swing N Swoosh". Steve Angello often tours with his brother and with his brother's partner, American DJ and producer Max Vangeli. Together AN21 & Max Vangeli, as they're more commonly known as, released the first non-compilation studio album in Size Records entitled People of the Night.